What is the active ingredient of Defensikan®?

The active ingredient in Defeniskan® is a mixture of bio-active polysaccharides called β-glucans, derived from the oyster mushroom (Pleurotus Ostreatus). These β-glucans have a positive effect on your immune system through activating certain signals to the M-cells in your gut.

In the video posted below, you can find the detailed mechanism of action of Defensikan®

 How does Defensikan®  influence your immune system?

As result of the M-cell activation, certain signals are expressed throughout your immune system, exerting various effects on various parts of both the innate and adaptive immune system. Through this activation, your immune system gets activated to provide a so-called trained immune response. This training can be seen as a work-out in the gym for your immune system: through training, the immune system becomes stronger and is better able to fight against pathogens in the future!

What is the result of this training?

The result of this training is that your body is better prepared against infections; by taking Defensikan® for three months consecutively, the amount of respiratory tract infections are reduced significantly. This is clinically proven in children1–3 and adults4!

  1. Jesenak M, Majtan J, Rennerova Z, Kyselovic J, Banovcin P, Hrubisko M. Immunomodulatory effect of pleuran (β-glucan from Pleurotus ostreatus) in children with recurrent respiratory tract infections. International Immunopharmacology. 2013;15(2):395-399. doi:10.1016/j.intimp.2012.11.020
  2. Jesenak M, Sanislo L, Kuniakova R, Rennerova Z, Buchanec J, Banovcin P. Imunoglukan P4H in the prevention of recurrent airway infections in children. Chesko-Slovenska Pediatrie. 2010;65(11):639-647.
  3. Pasnik J, Slemp A, Cywinska-Bernas A, Zeman K, Jesenak M. Preventive effect of pleuran (β-glucan from Pleurotus ostreatus) in children with recurrent respiratory tract infections – open-label prospective study. Curr Pediatr Res . 2017;21(1):99-104. www.currentpediatrics.com
  4. Urbancikova I, Hudackova D, Majtan J, Rennerova Z, Banovcin P, Jesenak M. Efficacy of Pleuran (β-Glucan from Pleurotus ostreatus) in the Management of Herpes Simplex Virus Type 1 Infection. Evidence-based Complementary and Alternative Medicine. 2020;2020. doi:10.1155/2020/8562309